Job Details

Sr. Staff Computational Protein Engineer (Enzyme Evolution / Design)

Company Overview

An early-stage genomics company developing next-generation innovations in sequencing and advanced nucleic acid detection.

The company is building:

• A single-molecule DNA sequencing technology designed to enable ultra-long read lengths, low error rates, and significantly reduced cost per genome
• A portable, field-deployable diagnostic platform capable of delivering rapid, high-sensitivity, sample-to-answer results in minutes

These technologies aim to expand access to genomic insights across research, clinical, and population-scale applications.

Position Overview

Seeking a Senior Staff Computational Protein Engineer to lead computational design and optimization of enzymes supporting next-generation sequencing and molecular detection platforms.

This individual will drive structure-based modeling, sequence optimization, and integration of computational approaches with experimental workflows, partnering closely with wet-lab teams to accelerate protein engineering efforts.

Key Responsibilities

• Lead computational protein engineering efforts, including enzyme design and optimization
• Apply structure-based modeling and simulation techniques to guide protein design
• Develop and implement strategies for sequence optimization and variant prioritization
• Integrate computational design with directed evolution and high-throughput screening workflows
• Collaborate closely with experimental (wet-lab) teams to validate and iterate on designs
• Analyze structural and functional data to inform next-generation protein variants
• Contribute to scientific strategy and provide technical leadership across programs

Qualifications

• PhD in Computational Biology, Protein Engineering, Biophysics, Structural Biology, Bioinformatics, or related field
• ~10–15+ years of industry experience
• Deep expertise in computational protein design, enzyme engineering, or structural modeling
• Experience leading computational efforts within protein engineering or directed evolution programs
• Strong understanding of structure–function relationships in proteins
• Proven ability to work cross-functionally with experimental teams
• Strong communication and leadership skills